منابع مشابه
Mechanistic studies on metabolic interactions between gemfibrozil and statins.
A series of studies were conducted to explore the mechanism of the pharmacokinetic interaction between simvastatin (SV) and gemfibrozil (GFZ) reported recently in human subjects. After administration of a single dose of SV (4 mg/kg p.o.) to dogs pretreated with GFZ (75 mg/kg p.o., twice daily for 5 days), there was an increase (approximately 4-fold) in systemic exposure to simvastatin hydroxy a...
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Calvacin is a potent, antitumor mucoprotein which is cumulative in effect and which causes a prolonged intoxication characterized by anorexia and extreme weight loss. It induces a wide spectrum of lesions in experimental mammals. The more promi nent include hepatic necrosis, biliary obstruction, renal tubular necrosis, fibrinoid degeneration, myofibrillar necrosis in cardiac and skeletal muscle...
متن کاملData management for toxicological studies.
Organized data management increases the reliability of statistical analysis. The basic purpose of data management is to assure the integrity and the quality of data. To assure data validity, establishing a checking system, such as data audit, would be desirable at the following points: protocol design, supervision of study schedule, definition of data, data collection, choice of tests and proce...
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Methanolic extract of Hairs and Glands covering fruits of Mallotus philippinensis (kamala powder) were subjected to Antimicrobial and toxicological screening. Antimicrobial profile indicated that extract was effective against all Gram positive cocci and bacilli used in the study. Among Gram negative bacilli, three important pathogenic species i.e. Salmonella typhi, Salmonella para typhiA and Ps...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of Medicine
سال: 1976
ISSN: 0035-9157
DOI: 10.1177/00359157760690s205